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Accurate diagnosis and prognosis assisted by pathology images are essential for cancer treatment selection and planning. Despite the recent trend of adopting deep-learning approaches for analyzing complex pathology images, they fall short as they often overlook the domain-expert understanding of tissue structure and cell composition. In this work, we focus on a challenging Open-ended Pathology VQA (PathVQA-Open) task and propose a novel framework named Path-RAG, which leverages HistoCartography to retrieve relevant domain knowledge from pathology images and significantly improves performance on PathVQA-Open. Admitting the complexity of pathology image analysis, Path-RAG adopts a human-centered AI approach by retrieving domain knowledge using HistoCartography to select the relevant patches from pathology images. Our experiments suggest that domain guidance can significantly boost the accuracy of LLaVA-Med from 38% to 47%, with a notable gain of 28% for H&E-stained pathology images in the PathVQA-Open dataset. For longer-form question and answer pairs, our model consistently achieves significant improvements of 32.5% in ARCH-Open PubMed and 30.6% in ARCH-Open Books on H\&E images. 

Recent advancements in large language models (LLMs) have achieved promising performances across various applications. Nonetheless, the ongoing challenge of integrating long-tail knowledge continues to impede the seamless adoption of LLMs in specialized domains. In this work, we introduce DALK, a.k.a. Dynamic Co-Augmentation of LLMs and KG, to address this limitation and demonstrate its ability on studying Alzheimer's Disease (AD), a specialized sub-field in biomedicine and a global health priority. With a synergized framework of LLM and KG mutually enhancing each other, we first leverage LLM to construct an evolving AD-specific knowledge graph (KG) sourced from AD-related scientific literature, and then we utilize a coarse-to-fine sampling method with a novel self-aware knowledge retrieval approach to select appropriate knowledge from the KG to augment LLM inference capabilities. The experimental results, conducted on our constructed AD question answering (ADQA) benchmark, underscore the efficacy of DALK. Additionally, we perform a series of detailed analyses that can offer valuable insights and guidelines for the emerging topic of mutually enhancing KG and LLM. 

Abstract Generation of electric voltage in a conductor by applying a temperature gradient is a fundamental phenomenon called the Seebeck effect. This effect and its inverse is widely exploited in diverse applications ranging from thermoelectric power generators to temperature sensing. Recently, a possibility of thermoelectricity arising from the interplay of the non-local Cooper pair splitting and the elastic co-tunneling in the hybrid normal metal-superconductor-normal metal structures was predicted. Here, we report the observation of the non-local Seebeck effect in a graphene-based Cooper pair splitting device comprising two quantum dots connected to an aluminum superconductor and present a theoretical description of this phenomenon. The observed non-local Seebeck effect offers an efficient tool for producing entangled electrons. 

Key-value (KV) stores play an increasingly critical role in supporting diverse large-scale applications in modern data centers hosting terabytes of KV items which even might reside on a single server due to virtualization purpose. The combination of ever growing volume of KV items and storage/application consolidation is driving a trend of high storage density for KV stores. Shingled Magnetic Recording (SMR) represents a promising technology for increasing disk capacity, but it comes at a cost of poor random write performance and severe I/O amplification. Applications/software working with SMR devices need to be designed and optimized in an SMR-friendly manner. In this work, we present SEALDB, a Log-Structured Merge tree (LSM-tree) based key-value store that is specifically op- timized for and works well with SMR drives via adequately addressing the poor random writes and severe I/O amplification issues. First, for LSM-trees, SEALDB concatenates SSTables of each compaction, and groups them into sets. Taking sets as the basic unit for compactions, SEALDB improves compaction efficiency by mitigating random I/Os. Second, SEALDB creates varying size bands on HM-SMR drives, named dynamic bands. Dynamic bands not only accommodate the storage of sets, but also eliminate the auxiliary write amplification from SMR drives. We demonstrate the advantages of SEALDB via extensive experiments in various workloads. Overall, SEALDB delivers impressive performance improvement. Compared with LevelDB, SEALDB is 3.42× faster on random load due to improved compaction efficiency and eliminated auxiliary write amplification on SMR drives.